Publications: NCCR TransCure

• Zaugg J, Solenthaler F, Albrecht Christiane “Materno-fetal iron transfer and the emerging role of ferroptosis pathways“ Biochemical Pharmacology (2022)

• Anderegg MA, Gyimesi G, Manh Ho T, Hediger MA, Fuster Daniel “The Less Well-Known Little Brothers: The SLC9B/NHA Sodium Proton Exchanger Subfamily—Structure, Function, Regulation and Potential Drug-Target Approaches“ Frontiers in Physiology (2022)

• Dhayat NA, Schneider L, Popp AW, Lüthi D, Mattmann C, Vogt B, Fuster Daniel “Predictors of Bone Mineral Density in Kidney Stone Formers“ Kidney International Reports (2022)

• Stauffer M, Jeckelmann J-M, Ilgü H, Ucurum Z, Boggavarapu R, Fotiadis Dimitrios “Peptide transporter structure reveals binding and action mechanism of a potent PEPT1 and PEPT2 inhibitor“ Commun Chem (2022)

• Moor MB, Dhayat NA, Schietzel S, Grössl M, Fuster Daniel “Urinary tetrahydroaldosterone is associated with circulating FGF23 in kidney stone formers“ Urolithiasis (2022)

• Karahoda R, Zaugg J, Fuenzalida B, Sampada K, Moser-Haessig R, Staud F, Albrecht Christiane “Trophoblast Differentiation Affects Crucial Nutritive Functions of Placental Membrane Transporters“ Frontiers in Cell and Developmental Biology (2022)

• Lüscher BP, Albrecht Christiane, Stieger B, Surbek D, Baumann MU “Glucose Transporter 9 (GLUT9) Plays an Important Role in the Placental Uric Acid Transport System“ Cells (2022)

• Biou V, Adaixo RJD, et al, Stahlberg Henning “Structural and molecular determinants for the interaction of ExbB from Serratia marcescens and HasB, a TonB paralog“ bioRxiv (2022)

• Alexander RT, Fuster Daniel, Dimke H “Mechanisms Underlying Calcium Nephrolithiasis“ Annual Review of Physiology (2022)

• Kowalczyk J, Budzyńska B, Kurach L, Pellegata D, El Sayed NS, Gertsch Jürg, Skalicka-Woźniak K “Neuropsychopharmacological profiling of scoparone in mice“ Scientific Reports (2022)

• Ramanadane K, Straub MS, Dutzler Raimund, Manatschal C “Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family“ eLife (2022)

• Adaixo R, Steiner E, Righetto RD, Schmidt A, Stahlberg Henning, Taylor N “Cryo-EM structure of native human thyroglobulin“ Nature Communications (2022)

• Ni D, Lau K, Turelli P, Raclot C, Beckert B, Nazarov S, Pojer F, Myasnikov A, Stahlberg Henning, Trono D “Structural analysis of the Spike of the Omicron SARS-COV-2 variant by cryo-EM and implications for immune evasion“ bioRxiv (2021)

• Di Castro MA, Volterra Andrea “Astrocyte control of the entorhinal cortex‐dentate gyrus circuit: Relevance to cognitive processing and impairment in pathology“ Glia (2021)

• Shahnawaz S, Nawaz US, Zaugg J, Hussain G, Malik N, Zahoor-ul-Hassan Dogar M, Malik SA, Albrecht Christiane “Dysregulated Autophagy Leads to Oxidative Stress and Aberrant Expression of ABC Transporters in Women with Early Miscarriage“ Antioxidants (2021)

• Ontsouka E, Epstein A, Kallol S, Zaugg J, Baumann M, Schneider H, Albrecht Christiane “Placental Expression of Bile Acid Transporters in Intrahepatic Cholestasis of Pregnancy“ Int J Mol Sci (2021)

• Schnyder D, Albano G, Kucharczyk P, Dolder S, Siegrist M, Anderegg M, Pathare G, Hofstetter W, Baron R, Fuster Daniel “Deletion of the sodium/hydrogen exchanger 6 causes low bone volume in adult mice“ Bone (2021)

• Bosshart PD, Kalbermatter D, Bonetti S, Fotiadis Dimitrios “The making of a potent L-lactate transport inhibitor“ Communications Chemistry (2021)

• Ilgü H, Jeckelmann J-M, Kalbermatter D, Ucurum Z, Lemmin T, Fotiadis Dimitrios “High-resolution structure of the amino acid transporter AdiC reveals insights into the role of water molecules and networks in oligomerization and substrate binding“ BMC Biology (2021)

• Ontsouka E, Lüthi M, Zaugg J, Schröder M, Albrecht Christiane “Establishment and validation of an approach allowing unequivocal fetal sex determination based on placental sex-specific genes“ Placenta (2021)

• Kantipudi S, Harder D, Bonetti S, Fotiadis Dimitrios, Jeckelmann J-M “Pichia pastoris and the Recombinant Human Heterodimeric Amino Acid Transporter 4F2hc-LAT1: From Clone Selection to Pure Protein“ Methods Protoc. (2021)

• Qin Y, Dongchun N, Kowal J, Manolaridis I, Scott MJ, Stahlberg Henning, Locher Kaspar “Structures of ABCG2 under turnover conditions reveal a key step in drug transport mechanism“ Nature Communications (2021)

• Arullampalam P, Preti B, Ross-Kaschitza D, Lochner Martin, Rougier J-S, Abriel Hugues “Species-Specific Effects of Cation Channel TRPM4 Small-Molecule Inhibitors“ Front Pharmacol (2021)

• Pujol-Giménez J, Poirier M, Bühlmann S, Schuppisser C, Bhardwaj R, Awale M, Visini R, Javor S, Hediger MA, Reymond Jean-Louis “Inhibitors of Human Divalent Metal Transporters DMT1 (SLC11A2) and ZIP8 (SLC39A8) from a GDB-17 Fragment Library“ ChemMedChem (2021)

• Bargagli M, Arena M, Naticchia A, Gambaro G, Mazzaferro S, Fuster Daniel, Ferraro PM “The Role of Diet in Bone and Mineral Metabolism and Secondary Hyperparathyroidism“ Nutrients (2021)

• Arullampalam P, Preti B, Ross-Kaschitza D, Lochner Martin, Rougier J-S, Abriel Hugues “Species-specific effects of cation channel TRPM4 small-molecule inhibitors“ Frontiers in Pharmacology (2021)

• Isaikina P , Tsai TJ, Dietz N, Pamula F, Grahal A, Goldie KN, Guixà-González R, Schertler GFX, Hartley O, Stahlberg Henning, Maier T, Deupi X, Grzesiek S “Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist.“ Science Advances (2021)

• Leuenberger M, Häusler S, Höhn V, Euler A, Stieger B, Lochner Martin “Characterization of Novel Fluorescent Bile Salt Derivatives for Studying Human Bile Salt and Organic Anion Transporters“ J Pharmacol Exp Ther (2021)

• Anderegg M, Liu M, Saganas C, Montani M, Vogt B, Hunyh-Do U, Fuster Daniel “De novo vasculitis after mRNA-1273 (Moderna) vaccination“ Kidney Int. (2021)

• Kantipudi S, Fotiadis Dimitrios “Yeast cell-based transport assay for the functional characterization of human 4F2hc-LAT1 and ‐LAT2, and LAT1 and LAT2 substrates and inhibitors“ Front. Mol. Biosci. (2021)

• Fuster Daniel “Metaphylaxe von Nierensteinen mittels medikamentöser und diätetischer Massnahmen“ Therapeutische Umschau (2021)

• Olinger E. et al, Fuster Daniel, et al. “Clinical and Genetic Spectra of Autosomal Dominant Tubulointerstitial Kidney Disease due to Mutations in UMOD and MUC1“ Kidney Int. (2021)

• Andrieu T, Chicca A, Pellegata D, Bersinger NA, Imboden S, Nirgianakis K, Gertsch Jürg, Mueller MD “Association of ECs with pain in endometriosis“ Pain (2021)

• Bargagli M, Ferraro PM, Dhayat N, Anderegg M, Fuster Daniel “Effect of Tolvaptan treatment on acid-base homeostasis in ADPKD patients“ Kidney International Reports (2021)

• Schneider H, Brownbill P, Albrecht Christiane “Ex vivo dual perfusion of an isolated cotyledon of human placenta: history and future challenges“ Placenta (2021)

• Kowal J, , Jackson SM, Manolaridis I, Stahlberg Henning, Locher Kaspar “Structural basis of drug recognition by the multidrug transporter ABCG2“ Journal of Molecular Biology (2021)

• Garrelfs SF et al, Fuster Daniel, et al “Lumasiran, an RNAi Therapeutic for Primary Hyperoxaluria Type 1“ N Engl J Med (2021)

• Reynoso-Moreno I, Tietz S, Vallini E, Engelhardt B, Gertsch Jürg, Chicca A “Selective Endocannabinoid Reuptake Inhibitor WOBE437 Reduces Disease Progression in a Mouse Model of Multiple Sclerosis“ ACS Pharmacol. Transl. Sci (2021)

• Ozhathil LC, Rougier JS, Arullampalam P, Essers MC, Ross-Kaschitza D, Abriel Hugues “Deletion of Trpm4 Alters the Function of the Nav1.5 Channel in Murine Cardiac Myocytes.“ Int J Mol Sci. (2021)

• Yan R, Li Y, Müller J, Zhang Y, Singer S, Xia L, Zhong X, Gertsch Jürg, Altmann Karl-Heinz, Zhou Q “Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter“ Cell Discov (2021)

• Botte M, Ni D, Schenck S, Zimmermann I, et al, , Stahlberg Henning “Insight into Lipopolysaccharide Translocation by Cryo-EM structures of a LptDE Transporter in Complex with Pro-Macrobodies“ bioRxiv (2021)

• Schietzel S, Moor MB, Fuster Daniel “Severe Hypomagnesemia“ J Nephrol (2021)

• Hu Y, Ross-Kaschitza DR, Essers M, Arullampalam P, Fujita T, Abriel Hugues, Inoue R “Pathological activation of CaMKII induces arrhythmogenicity through TRPM4 overactivation.“ Pflugers Arch. (2021)

• Escartin C, Galea E, Lakatos A, et. al, Volterra Andrea “Reactive astrocyte nomenclature, definitions, and future directions“ Nature Neuroscience (2021)

• Karahoda R, Kallol S, Grössl M, Ontsouka E, Anderle P, Flück C, Staud F, Albrecht Christiane “Revisiting steroidogenic pathways in the human placenta and primary human trophoblast cells“ Int J Mol Sci (2021)

• Borgström A, Peinelt Christine, Stocklosa P “TRPM4 in Cancer-A New Potential Drug Target“ Biomolecules (2021)

• Fuenzalida B, Kallol S, Lüthi M, Albrecht Christiane, Leiva A “The polarized localization of lipoprotein receptors and cholesterol transporters in the syncytiotrophoblast of the placenta is reproducible in a monolayer of primary human trophoblasts“ Placenta (2021)

• Verouti SN, Lambert D, Mathis D, Pathare G, Escher G, Vogt B, Fuster Daniel “The solute carrier SLC16A12 is critical for creatine and guanidinoacetate handling in the kidney“ Am J Physiol Renal Physiol (2021)

• Granchi C , Bononi G, Ferrisi R, Gori E, Mantini G, Glasmacher S, Poli G, Palazzolo S, Caligiuri I, Rizzolio F, Canzonieri V, Perin T, Gertsch Jürg, et al “Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors“ Eur J Med Chem (2021)

• Righetto R, Stahlberg Henning “Single particle analysis for high-resolution 2D electron crystallography“ Methods in Molecular Biology (2020)

• Fuster Daniel, Morard GA, Schneider L, Mattmann C, Lüthi D, Vogt B, Dhayat NA “Association of urinary sex steroid hormones with urinary calcium, oxalate and citrate excretion in kidney stone formers“ Nephrol Dial Transplant (2020)

• Tsaturyan A, Bokova E, Bosshard P, Bonny O, Fuster Daniel, Roth B “Oral chemolysis is an effective, non-invasive therapy for urinary stones suspected of uric acid content“ Urolithiasis (2020)

• Bhardwaj R et al, Reymond Jean-Louis, Hediger MA, et al “Inactivation-mimicking block of the epithelial calcium channel TRPV6“ Science Advances (2020)

• Botte M , Ulrich AKC, Adaixo R, Gnutt D, Brockmann A, Bucher D, Chami M, Bocquet N, Ebbinghaus-Kintscher U, Puetter V, Becker A, Egner U, Stahlberg Henning, Holton SJ “Cryo-EM structural studies of the agonist complexed human TRPV4 ion-channel reveals novel structural rearrangements resulting in an open-conformation“ bioRxiv (2020)

• Williams JC et al, Fuster Daniel, et al “Urine and Stone Analysis for the Investigation of the Renal Stone Former: A Consensus Conference“ Urolithiasis (2020)

• Borgström A, Hauert B, Kappel S, Zoni E, Kiener M, Stocklosa P, Baur R, Spahn M, Kruithof de Julio M, Peinelt Christine “Small Molecular Inhibitors Block TRPM4 Currents in Prostate Cancer Cells, with Limited Impact on Cancer Hallmark Functions“ Journal of Molecular Biology (2020)

• Ni D, Lau K, Lehmann F, Fränkl A, Hacker D, Pojer F, Stahlberg Henning “Structural investigation of ACE2 dependent disassembly of the trimeric SARS-CoV-2 Spike glycoprotein“ bioRxiv (2020)

• Zaugg J, Huang X, Ziegler F, Rubin M, Graff J, Müller J, Moser‐Hässig R, Powell T, Gertsch Jürg, Altmann Karl-Heinz, Albrecht Christiane “Small molecule inhibitors provide insights into the relevance of LAT1 and LAT2 in materno‐foetal amino acid transport“ Journal of Cellular and Molecular Medicine (2020)

• Acebrón I, Righetto R, Schoenher C, de Buhr S, Redondo P, Culley J, Rodríguez CF, Daday C, Biyani N, Llorca O, Byron A, Chami M, Gräter F, Boskovic J, Frame MC, Stahlberg Henning, Lietha D “Structural basis of Focal Adhesion Kinase activation on lipid membranes.“ EMBO J (2020)

• Zaugg J, Ziegler F, Nuoffer JM, Moser-Hässig R, Albrecht Christiane “Counter-directed leucine gradient promotes amino acid transfer across the human placenta.“ Journal of Nutritional Biochemistry (2020)

• Arena C et al, Gertsch Jürg, et al “The endocannabinoid system dual-target ligand N-cycloheptyl-1,2-dihydro-5-bromo-1-(4-fluorobenzyl)-6-methyl-2-oxo-pyridine-3-carboxamide improves disease severity in a mouse model of multiple sclerosis“ Eur J Med Chem (2020)

• Jeckelmann JM, Fotiadis Dimitrios “Sub-nanometer cryo-EM density map of the human heterodimeric amino acid transporter 4F2hc-LAT2“ Int. J. Mol. Sci. (2020)

• Jeckelmann JM, Hüseyin I, Bosshart PD, Fotiadis Dimitrios “A procedure and double-chambered device for macromolecular crystal flash-cooling in different cryogenic liquids“ PLoS One (2020)

• Anderegg MA, Albano G, Hanke D, Bhardwaj R, Hediger Matthias A., Fuster Daniel “The sodium/proton exchanger NHA2 regulates blood pressure through a WNK4-NCC dependent pathway in the kidney“ Kidney Int. (2020) [Press release]

• Karahoda R, Abad C, Horackova H, Kastner P, Zaugg J, Cerveny L, Kucera R, Albrecht Christiane, Staud F “Dynamics of tryptophan metabolic pathways in human placenta and placental-derived cells; effect of gestation age and trophoblast differentiation.“ Front Cell Dev Biol (2020)

• Karahoda R, Abad C, Horackova H, Kastner P, Zaugg J, Cerveny L, R. Kuccera, Albrecht Christiane, Staud F “Dynamics of tryptophan metabolic pathways in human placenta and placental-derived cells; effect of gestation age and trophoblast differentiation“ Front Cell Dev Biol (2020)

• Kantipudi S, Jeckelmann J-M, Ucurum Z, Bosshart PD, Fotiadis Dimitrios “The Heavy Chain 4F2hc Modulates the Substrate Affinity and Specificity of the Light Chains LAT1 and LAT2“ Int. J. Mol. Sci. (2020)

• Sarott RC et al, Gertsch Jürg, et al “Development of High-Specificity Fluorescent Probes to Enable Cannabinoid Type 2 Receptor Studies in Living Cells“ J Am Chem Soc (2020)

• Righetto R, Anton L, Rima L, Jakob RP, Zivanov J, Mahi MA, Ringler P, Schwede T, Maier T, Stahlberg Henning “High-resolution cryo-EM structure of urease from the pathogen Yersinia enterocolitica.“ Nature Comm (2020)

• Bosshart PD, Charles R-P, Garibsingh R-A, Schlessinger A, Fotiadis Dimitrios “SLC16 Family: From Atomic Structure to Human Disease“ Trends in Biochemical Sciences (2020)

• Sears AE, Albiez A, Gulati S, Wang B, Kiser P, Kovacik L, Engel A, Stahlberg Henning, Palczewski K “Single particle cryo-EM of the complex between interphotoreceptor retinoid-binding protein and a monoclonal antibody.“ FASEB J (2020)

• Schild A, Bhardwaj R, Wenger N, Tscherrig D, Kandasamy P, Dernič J, Baur R, Peinelt Christine, Hediger MA, Lochner Martin “Synthesis and Pharmacological Characterization of 2-Aminoethyl Diphenylborinate (2-APB) Derivatives for Inhibition of Store-Operated Calcium Entry (SOCE) in MDA-MB-231 Breast Cancer Cells“ Int. J. Mol. Sci. (2020)

• Bargagli M, Dhayat NA, Anderegg M, Semmo M, Huynh-Do U, Vogt B, Ferraro PM, Fuster Daniel “Urinary Lithogenic Risk Profile in ADPKD Patients Treated with Tolvaptan“ Clin J Am Soc Nephrol (2020)

• Capecchi A, Probst D, Reymond Jean-Louis “One molecular fingerprint to rule them all: drugs, biomolecules, and the metabolome“ J Cheminform (2020)

• Stokłosa P, Probst D, Reymond Jean-Louis, Peinelt Christine “The name tells the story: Two-pore channels“ Cell Calcium (2020)

• Poirier M, Pujol-Giménez J, Manatschal C, Bühlmann S, Embaby A, Javor S, Hediger Matthias A., Reymond Jean-Louis “Pyrazolyl-pyrimidones inhibit the function of human solute carrier protein SLC11A2 (hDMT1) by metal chelation“ RCS Medicinal Chemistry (2020)

• Altmann Karl-Heinz, Mäder P, Bartholomäus R, Nicolussi S, Baumann A, Weis M, Chicca A, Rau M, Simão AC, Gertsch Jürg “Synthesis and Biological Evaluation of Endocannabinoid Uptake Inhibitors Derived from WOBE437“ ChemMedChem (2020)

• Drożdżyk K, Sawicka M, Bahamonde-Santos M, Zaugg J, Deneka D, Albrecht Christiane, Dutzler Raimund “Cryo-EM Structures and Functional Properties of CALHM Channels of the Human Placenta“ Elife (2020)

• Kallol S, Albrecht Christiane “Materno-fetal Cholesterol Transport During Pregnancy“ Biochem Soc Trans (2020)

• Zaugg J, Melhem H, Huang X, Wegner M, Baumann M, Surbek D, Körner M, Albrecht Christiane “Gestational Diabetes Mellitus Affects Placental Iron Homeostasis: Mechanism and Clinical Implications“ FASEB J (2020)

• Kappel S, Kilch T, Baur R, Lochner Martin, Peinelt Christine “The Number and Position of Orai3 Units Within Heteromeric Store-Operated Ca 2+ Channels Alter the Pharmacology of I CRAC“ Int J Mol Sci. (2020)

• Dhayat NA, Pruijm M, Ponte B, Ackermann D, Leichtle AB, Devuyst O, Ehret G, Guessous I, Pechère-Bertschi A, Pastor J, Martin P-Y, Burnier M, Fiedler G-M, Vogt B, Moe OW, Bochud Murielle, Fuster Daniel “Parathyroid Hormone and Plasma Phosphate Are Predictors of Soluble α-Klotho Levels in Adults of European Descent“ J Clin Endocrinol Metab (2020)

• Zhang ZY, Carmeli C, Ponte B, Pruijm M, Ackermann D, Ehret G, Guessous I, Petrović D, Pechère-Bertschi A, Vogt B, Martin P-Y, Burnier M, Lenglet S, Augsburger M, Thomas A, Bochud Murielle “Ambulatory Blood Pressure in Relation to Plasma and Urinary Manganese“ Hypertension (2020)

• Saliakoura M, Reynoso-Moreno I, Pozzato C, Rossi Sebastiano M, Galié M, Gertsch Jürg, Konstantinidou G “The ACSL3-LPIAT1 Signaling Drives Prostaglandin Synthesis in Non-Small Cell Lung Cancer“ Oncogene (2020)

• Antoni F, Bause M, Scholler M, Bauer S, Stark SA, Jackson SM, Manolaridis J, Locher Kaspar, König B, Buschauer A, Bernhardt G “Tariquidar-related triazoles as potent, selective and stable inhibitors of ABCG2 (BCRP)“ Eur J Med Chem (2020)

• Fuenzalida B, Cantin C, Kallol S, Carvajal L, Pastén V, Contreras-Duarte S, Albrecht Christiane, Gutierrez J, Leiva A “Cholesterol Uptake and Efflux Are Impaired in Human Trophoblast Cells From Pregnancies With Maternal Supraphysiological Hypercholesterolemia“ Sci Rep (2020)

• Bhardwaj R, Augustynek BS, Ercan-Herbst E, Kandasamy P, Seedorf M, Peinelt Christine, Hediger Matthias A. “Ca 2+/Calmodulin Binding to STIM1 Hydrophobic Residues Facilitates Slow Ca 2+-Dependent Inactivation of the Orai1 Channel“ Cell Physiol Biochem (2020)

• Stoklosa P, Borgström A, Kappel S, Peinelt Christine “TRP Channels in Digestive Tract Cancers“ Int. J. Mol. Sci. (2020)

• Kucharava K, Brand Y, Albano G, Sekulic-Jablanovic, Glutz A, Xian X, Herz J, Bodmer D, Fuster Daniel, Petkovic V “Sodium-hydrogen Exchanger 6 (NHE6) Deficiency Leads to Hearing Loss, via Reduced Endosomal Signalling Through the BDNF/Trk Pathway“ Sci Rep (2020)

• Anderegg MA, Dhayat NA, Semmo M, Huynh-Do U, Vogt B, Fuster Daniel “Quality of Life in Autosomal Dominant Polycystic Kidney Disease Patients Treated With Tolvaptan“ Kidney Medicine (2020)

• Gado F, Arena C, Fauci C, Reynoso Moreno I, Bertini S, Digiacomo M, Meini S, Poli G, Macchia M, Tuccinardi T, Gertsch Jürg, Chicca A, Manera C “Modification on the 1,2-dihydro-2-oxo-pyridine-3-carboxamide Core to Obtain Multi-Target Modulators of Endocannabinoid System“ Bioorg Chem. (2020)

• Arús-Pous J, Awale M, Probst D, Reymond Jean-Louis “Exploring Chemical Space With Machine Learning“ Chimia (Aarau) (2019)

• Guerrero-Ferreira R, Taylor NM, Arteni AA, Kumari P, Mona D, Ringler P, Britschgi M, Lauer ME, Makky A, Verasdonck J, Riek R, Melki R, Meier BH, Böckmann A, Bousset L, Stahlberg Henning “Two New Polymorphic Structures of Human Full-Length Alpha-Synuclein Fibrils Solved by Cryo-Electron Microscopy“ Elife (2019)

• Manatschal C, Pujol-Giménez J, Poirier M, Reymond Jean-Louis, Hediger Matthias A., Dutzler Raimund “Mechanistic Basis of the Inhibition of SLC11/NRAMP-mediated Metal Ion Transport by Bis-Isothiourea Substituted Compounds“ Elife (2019) [Data repository]

• Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Amstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA, Beuve A, Boison D, Brouckaert P, Burnett JC, Burns K, Dessauer C, Friebe A, Garthwaite J, Gertsch Jürg, et al. “The concise guide to Pharmacology 2019/20: Enzymes“ (2019)

• Lewis AJ, Jenoud C, Pont M, van de Bern W, Frank S, Stahlberg Henning, Shahmoradian SH, Al-Amoudi A “Imaging of Post-Mortem Human Brain Tissue Using Electron and X-ray Microscopy“ Curr Opin Struct Biol (2019)

• Kappel S, Stokłosa P, Hauert B, Ross-Kaschitza D, Borgström A, Baur R, Galván JA, Zlobec I, Peinelt Christine “TRPM4 Is Highly Expressed in Human Colorectal Tumor Buds and Contributes to Proliferation, Cell Cycle, and Invasion of Colorectal Cancer Cells“ Mol Oncol. (2019)

• Bartholomäus R, Nicolussi S, Baumann A, Rau M, Simão AC, Gertsch Jürg, Altmann Karl-Heinz “Total Synthesis of the Endocannabinoid Uptake Inhibitor Guineensine and SAR Studies“ ChemMedChem (2019)

• Lüscher BP, Surbek D, Clémençon B, Huang X, Albrecht Christiane, Marini C, Hediger Matthias A., Baumann MU “Different Pharmacological Properties of GLUT9a and GLUT9b: Potential Implications in Preeclampsia“ Cell Physiol Biochem (2019)

• Bosshart PD, Kalbermatter D, Bonetti S, Fotiadis Dimitrios “Structure and Function of a Monocarboxylate Transporter Homolog Specific for L-lactate“ Mol. Cell. Oncol. (2019)

• Probst D, Reymond Jean-Louis “Visualization of Very Large High-Dimensional Data Sets as Minimum Spanning Trees (Preprint)“ ChemRxiv (2019)

• Wiegand A, Fisher G, Seeger H, Fuster Daniel, Dhayat N, Bonny O, Ernandez T, Kim M-J, Wagner CA, Mohebbi N “Impact of potassium citrate on urinary risk profile, glucose and lipid metabolism of kidney stone formers in Switzerland“ Clinical Kidney Journal (2019)

• Cunha MR, Bhardwaj R, Lindinger S, Butorac C, Romanin C, Hediger M, Reymond Jean-Louis “Photoswitchable Inhibitor of the Calcium Channel TRPV6“ ACS Medicinal Chemistry Letters (2019)

• Tsai C-J, Marino J, Adaixo R, Pamula F, Muehle J, Maeda S, Flock T, Taylor NM, Mohammed I, Matile H, Dawson RJP, Deupi X, Stahlberg Henning, Schertler G “Cryo-EM Structure of the rhodopsin-Gαi-βγ Complex Reveals Binding of the Rhodopsin C-terminal Tail to the Gβ Subunit“ Elife (2019)

• Bosshart PD, Fotiadis Dimitrios “ Secondary active transporters“ Subcell Biochem . (2019)

• Bosshart PD, Kalbermatter D, Bonetti S, Fotiadis Dimitrios “Mechanistic basis of L-lactate transport in the SLC16 solute carrier family“ Nature Communications (2019)

• Ferraro PM, Arrabal-Polo MA, Capasso G, Croppi E, Cupisti A, Ernandez T, Fuster Daniel, et al. “A Preliminary Survey of Practice Patterns Across Several European Kidney Stone Centers and a Call for Action in Developing Shared Practice“ Urolithiasis (2019)

• Stergachis AB, Pujol-Giménez J, Gyimesi G, Fuster Daniel, Albano G, Troxler M, Picker J, Rosenberg PA, Bergin A, Peters J, El Achkar CM, Harini C, Manzi S, Rotenberg A, , Hediger MA, Rodan LH “Recurrent SLC1A2 variants cause epilepsy via a dominant negative mechanism“ Ann Neurol. (2019)

• Savtchouk I, Di Castro MA, Ali R, Stubbe H, Lujan R, Volterra Andrea “Circuit-specific control of the medial entorhinal inputs to the dentate gyrus by atypical presynaptic NMDARs activated by astrocytes“ PNAS (2019)

• Häfliger P, “The L-Type Amino Acid Transporter LAT1-An Emerging Target in Cancer“ Int J Mol Sci. (2019)

• Jeckelmann JM, Fotiadis Dimitrios “The structure of the human 4F2hc-LAT1 heteromeric amino acid transporter“ Sci. China Life Sci. (2019)

• Mehlem H, Kallol S, Huang X, Lüthi M, Ontsuka CE, Keogh A, Stroka D, Thormann W, Schneider H, Albrecht Christiane “Placental secretion of apolipoprotein A1 and E: the anti-atherogenic impact of the placenta“ Scientific Reports (2019)

• Righetto RD, Biyani N, Kowal J, Chami M, Stahlberg Henning “Retrieving high-resolution information from disordered 2D crystals by single-particle cryo-EM“ Nature Communications (2019)

• Gyimesi G, Albano G, Fuster Daniel, Hediger MA, Pujol-Gimenez J “Unraveling the structural elements of pH sensitivity and substrate binding in the human zinc transporter SLC39A2 (ZIP2)“ J. Biol. Chem. (2019)

• Granchi C, Lapillo M, Glasmacher S, Bononi G, Licari C, Poli G, El Boustani M, Caligiuri I, Rizzolio F, Gertsch Jürg, Macchia M, Minutolo F, Tuccinardi T, Chicca A “Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor.“ J Med Chem (2019)

• Jeckelmann JM, Fotiadis Dimitrios “Volta Phase Plate Cryo-EM Structure of the Human Heterodimeric Amino Acid Transporter 4F2hc-LAT2“ Int J Mol Sci (2019)

• Alam A, Koval J, Broude E, Roninson I, Locher Kaspar “Structural insight into substrate and inhibitor discrimination by human P-glycoprotein“ Science (2019)

• Faller N, Dhayat NA, Fuster Daniel “Nephrolithiasis Secondary to Inherited Defects in the Thick Ascending Loop of Henle and Connecting Tubules“ Urolithiasis (2019)

• Santello M, Toni N, Volterra Andrea “Astrocyte function from information processing to cognition and cognitive impairment.“ Nat Neurosci (2019)

• Awale M, Reymond Jean-Louis “Web-Based Tools for Polypharmacology Prediction“ J Chem Inf Model (2019)

• Awale M, Reymond Jean-Louis “Polypharmacology Browser PPB2: Target Prediction Combining Nearest Neighbors with Machine Learning“ J Chem Inf Model (2019)

• Delalande C, Awale M, Rubin M, Probst D, Ozhathil LC, Gertsch Jürg, Abriel Hugues, Reymond Jean-Louis “Optimizing TRPM4 inhibitors in the MHFP6 chemical space“ Eur J Med Chem (2019)

• Poirier M, Awale M, Roelli MA, Giuffredi GT, Ruddigkeit L, Evensen L, Stooss A, Calarco S, Lorens JB, , Reymond Jean-Louis “Identifying Lysophosphatidic Acid Acyltransferase β (LPAAT-β) as the Target of a Nanomolar Angiogenesis Inhibitor from a Phenotypic Screen Using the Polypharmacology Browser PPB2“ ChemMedChem (2019)

• Kappel S, Borgström A, Stocklosa P, Dörr K, Peinelt Christine “Store-operated calcium entry in disease: Beyond STIM/Orai expression levels“ Seminars in Cell & Developmental Biology (2019)

• Probst D, Reymond Jean-Louis “A probabilistic molecular fingerprint for big data settings“ J Cheminform. (2018)

• Kallol S, Moser-Haessig R, Ontsouka CE, Albrecht Christiane “Comparative expression patterns of selected membrane transporters in differentiated BeWo and human primary trophoblast cells“ Placenta (2018)

• ElMokh O, Taelmann V, Radojewski P, Roelli MA, Stooss A, Dumont RA, Dettmer M, Phillips W, Walter MA, “MEK inhibition induces therapeutic iodine uptake in a murine model of anaplastic thyroid cancer.“ J Nucl Med. (2018)

• Manolaridis I, Jackson SM, Taylor NMI, Kowal J, Stahlberg Henning, Locher Kaspar “Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states“ Nature (2018)

• Chicca A, Schafroth MA, Reynoso-Moreno I, Erni R, Petrucci V, Carreira EM, Gertsch Jürg “Uncovering the psychoactivity of a cannabinoid from liverworts associated with a legal high“ Science Advances (2018)

• Tamò L, Hibaoui Y, Kallol S, Alves MP, Albrecht Christiane, Hostettler KE, Feki A, Rougier JS, Abriel Hugues, Knudsen L, Gazdhar A, Geiser T “Generation of an alveolar epithelial type II cell line from induced pluripotent stem cells“ Am J Physiol Lung Cell Mol Physiol. (2018)

• Häfliger P, Graff J, Rubin M, Stoss A, Dettmer MS, Altmann Karl-Heinz, Gertsch Jürg, “The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model.“ Journal of Experimental & Clinical Cancer Research (2018)

• Petrelli F, Dallérac G, Pucci L, Calì C, Zehnder T, Sultan S, Lecca S, Chicca A, Ivanov A, Asensio CS, Gundersen V, Toni N, Knott GW, Magara F, Gertsch Jürg, Kirchhoff F, Déglon N, Edwards RH, Mothet J-P, , , Bezzi P “Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments“ Molecular Psychiatry (2018)

• Kallol S, Huang X, Müller S, Ontsouka CE, Albrecht Christiane “Novel Insights into Concepts and Directionality of Maternal⁻Fetal Cholesterol Transfer across the Human Placenta“ Int J Mol Sci. (2018)

• Biyani N, Scherer S, Righetto RD, Kowal J, Chami M, Stahlberg Henning “Image processing techniques for high-resolution structure determination from badly ordered 2D crystals“ J Struct Biol. (2018)

• Bianchi B, Smith PA, Abriel Hugues “The ion channel TRPM4 in murine experimental autoimmune encephalomyelitis and in a model of glutamate-induced neuronal degeneration“ Molecular Brain (2018)

• Franz MC, Pujol-Giménez J, Montalbetti N, Fernandez-Tenorio M, DeGrado TR, Niggli E, , Hediger M “Reassessment of the Transport Mechanism of the Human Zinc Transporter SLC39A2“ Biochemistry (2018)

• Fuster Daniel, Moe OW “ Incomplete distal renal tubular acidosis and kidney stones. “ Advances in chronic kidney disease (2018)

• Chicca A, Arena C, Bertini S, Gado F, Ciaglia E, Abate M, Digiacomo M, Lapillo M, Poli G, Bifulco M, Macchia M, Tuccinardi T, Gertsch Jürg, Manera C “ Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system“ Eur J Med Chem (2018)

• Reynoso-Moreno I, Chicca A, Flores-Soto ME, Viveros-Paredes JM , Gertsch Jürg “The endocannabinoid reuptake inhibitor WOBE437 is orally bioavailable and exerts indirect polypharmacological effects via different endocannabinoid receptors“ Front. Mol. Neurosci. (2018)

• M. Schroeder, M. Jakovcevski, T. Polacheck, Y. Drori, A. Luoni, S. Röh, J. Zaugg, S. Ben-Dor, Albrecht Christiane, A. Chen “Placental miR-340 mediates vulnerability to activity based anorexia in mice“ Nature Communications (2018)

• Tournier N, Langer O, Stieger B “Imaging techniques to study drug transporter function in vivo“ Pharmacol Ther (2018)

• Savtchouk I, Carriero G, Volterra Andrea “Studying Axon-Astrocyte Functional Interactions by 3D Two-Photon Ca2+ Imaging: A Practical Guide to Experiments and “Big Data” Analysis“ Front Cell Neurosci. (2018)

• Jackson SM, Manolaridis I, Koval J, Zechner M, Taylor NMI, Bauer S, Bartholomaeus, R, Bernhardt G, Koenig B, Buschauer A, Stahlberg Henning, Altmann Karl-Heinz, Locher Kaspar “Structural basis of small-molecule inhibition of human multidrug transporter ABCG2. “ Nat Struct Mol Biol (2018)

• Ozhathil LC,, Delalande C, Bianchi B, Nemeth G, Kappel S, Thomet U, Ross‐Kaschitza , Simonin C, Rubin M, Gertsch Jürg, Lochner Martin, Peinelt Christine, Reymond Jean-Louis, “Identification of potent and selective small molecule inhibitors of the cation channel TRPM4“ British Journal of Pharmacology (2018)

• Clémençon B, Lüscher BP, Hediger M “Establishment of a novel microscale thermophoresis ligand-binding assay for characterization of SLC solute carriers using oligopeptide transporter PepT1 (SLC15 family) as a model system“ J Pharmacol Toxicol Methods. (2018)

• Ilgü H, Jeckelmann JM, Colas C, Ucurum Z, Schlessinger A, Fotiadis Dimitrios “Effects of Mutations and Ligands on the Thermostability of the l-Arginine/Agmatine Antiporter AdiC and Deduced Insights into Ligand-Binding of Human l-Type Amino Acid Transporters“ Int J Mol Sci. (2018)

• Bianchi B, Ozhathil LC, Medeiros-Domingo A, Gollob MH, Abriel Hugues “Four TRPM4 Cation Channel Mutations Found in Cardiac Conduction Diseases Lead to Altered Protein Stability“ Front Physiol. (2018)

• Zákány N, Oláh A, Markovics A, Takács E, Aranyász A, Nicolussi S, Piscitelli F, Allarà M, Pór Á, Kovács I, Zouboulis CC, Gertsch Jürg, Di Marzo V, Bíró T, Szabó T “Endocannabinoid Tone Regulates Human Sebocyte Biology“ J Invest Dermatol. (2018)

• Huang X, Anderle P, Hostettler L, Baumann MU, Surbek DV, Ontsouka EC, Albrecht Christiane “Identification of placental nutrient transporters associated with intrauterine growth restriction and pre-eclampsia“ BMC Genomics (2018)

• McLeod RA, Diogo Righetto R, Stewart A, Stahlberg Henning “MRCZ - A file format for cryo-TEM data with fast compression“ Journal of structural biology (2018)

• Alam A, Küng R, Kowal J, McLeod RA, Tremp N, Broude EV, Roninson IB, Stahlberg Henning, Locher Kaspar “Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1“ PNAS (2018)

• Pathare G, Anderegg M, Albano G, Lang F, Fuster Daniel “Elevated FGF23 Levels in Mice Lacking the Thiazide-Sensitive NaCl cotransporter (NCC)“ Scientific Reports (2018)

• Aghazadeh Tabrizi M, Baraldi PG, Baraldi S, Ruggiero E, De Stefano L, Rizzolio F, Di Cesare Mannelli L, Ghelardini C, Chicca A, Lapillo M, Gertsch Jürg, Manera C, Macchia M, Martinelli A, Granchi C, Minutolo F, Tuccinardi T “Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors“ J Med Chem (2018)

• Castano-Diez D, Kudryashev M, Stahlberg Henning “Geometrical tools and data management for particle picking in subtomogram averaging of cryo-electron tomograms.“ Journal of structural biology (2018)

• Petrelli F, Bezzi P “mGlu5-mediated signalling in developing astrocyte and the pathogenesis of autism spectrum disorders“ Curr Opin Neurobiol (2018)

• Probst D, Reymond Jean-Louis “SmilesDrawer: parsing and drawing SMILES-encoded molecular structures using client-side JavaScript“ J. Chem. Inf. Model. (2018)

• Sedzicki J, Tschon T, Huey Low S, Willemart K, Goldie KN, Letesson JJ, Stahlberg Henning, Dehio C “3D correlative electron microscopy reveals continuity of Brucella-containing vacuoles with the endoplasmic reticulum.“ J Cell Sci (2018)

• Pathare G, Dhayat N, Mohebbi N, Wagner C, Bobulescu IA, Moe OW, Fuster Daniel “Changes in V-ATPase subunits of human urinary exosomes reflect the renal response to acute acid/alkali loading and the defects in distal renal tubular acidosis“ Kidney International (2018)

• Savtchouk I, Volterra Andrea “Gliotransmission: Beyond Black-and-White.“ Journal of Neuroscience (2018)

• Kowal J, Biyani N, Chami M, Scherer S, Rzepiela AJ, Baumgartner P, Upadhyay V, Nimigean CM, Stahlberg Henning “High-Resolution Cryoelectron Microscopy Structure of the Cyclic Nucleotide-Modulated Potassium Channel MloK1 in a Lipid Bilayer.“ Structure (2018)

• Dhayat N et al. “Distinct phenotype of kidney stone formers with renal phosphate leak (in press)“ Nephrology Dialysis Transplantation (2018)

• Nazarov S, Schneider JP, Brackmann M, Goldie KN, Stahlberg Henning, Basler M “ Cryo-EM reconstruction of Type VI secretion system baseplate and sheath distal end“ The EMBO journal (2017)

• Bertini S, Chicca A, Gado F, Arena C, Nieri D, Digiacomo M, Saccomanni G, Zhao P, Abood ME, Macchia M, Gertsch Jürg, Manera C “Novel analogs of PSNCBAM-1 as allosteric modulators of cannabinoid CB1 receptor“ Bioorg Med Chem (2017)

• Kappel S, Marques IJ, Zoni E, Stokłosa P, Peinelt Christine, Mercader N, Kruithof-de Julio M, Borgström A “Store-Operated Ca2+ Entry as a Prostate Cancer Biomarker — a Riddle with Perspectives“ Curr. Mol. Biol. Reports (2017)

• Probst D, Reymond Jean-Louis “FUn: A Framework for Interactive Visualizations of Large, High Dimensional Datasets on the Web“ Bioinformatics (2017)

• Reynoso-Moreno I, Najar-Guerrero I, Escareño N, Flores-Soto ME, Gertsch Jürg, Viveros-Paredes JM “An Endocannabinoid Uptake Inhibitor from Black Pepper Exerts Pronounced Anti-Inflammatory Effects in Mice“ J Agric Food Chem (2017)

• S. Chen, X. Huang, S. Decurtins, Albrecht Christiane, Shi-Xia Liu “A terpy-functionalized benzodifuran-based fluorescent probe for in vitro monitoring cellular Zn(II) uptake“ Polyhedron (2017)

• Wang J, Brackmann M, Castaño-Díez D, Kudryashev M, Goldie KN, Maier T, Stahlberg Henning, Basler M “ Cryo-EM structure of the extended type VI secretion system sheath-tube complex“ Nature microbiology (2017)

• Pathare G, Dhayat N, Mohebbi N, Wagner C, Cheval L, Neuhaus TJ, Fuster Daniel “Acute regulated expression of pendrin in human urinary exosomes“ Pflugers Arch (2017)

• Dhayat NA, Gradwell MW, Pathare G, Anderegg M, Schneider L, Luethi D, Mattmann C, Moe OW, Vogt B, Fuster Daniel “Furosemide/Fludrocortisone Test and Clinical Parameters to Diagnose Incomplete Distal Renal Tubular Acidosis in Kidney Stone Formers“ Clin J Am Soc Nephrol (2017)

• Di Bonaventura I, Jin X, Visini R, Probst D, Javor S, Gan BH, Michaud G, Natalello A, Doglia SM, Köhler T, von Delden C, Stocker A, Darbrea T, Reymond Jean-Louis “Chemical space guided discovery of antimicrobial bridged bicyclic peptides against Pseudomonas aeruginosa and its biofilms“ Chem. Sci. (2017) [Press release]

• Patsenker E, Chicca A, Petrucci V, Moghadamrad S, de Gottardi A, Semmo N, Gertsch Jürg, Stickel F “4-O’-methylhonokiol protects from alcohol/carbon tetrachloride-induced liver injury in mice“ J. Mol. Med (2017)

• Kalbermatter D, Chiu P, Jeckelmann JM, Ucurum Z, Walz T, Fotiadis Dimitrios “Electron crystallography reveals that substrate release from the PTS IIC glucose transporter is coupled to a subtle conformational change“ J Struct Biol (2017)

• Chicca A, Nicolussi S, Bartholomäus R, Blunder M, Aparisi Rey A, Petrucci V, del Carmen Reynoso-Moreno I, Viveros-Paredes M, Dalghi Gens M, Lutz B, Schiöth HB, Soeberdt M, Abels C, , Altmann Karl-Heinz, Gertsch Jürg “Chemical probes to potently and selectively inhibit endocannabinoid cellular reuptake“ PNAS (2017) [Press release]

• Taylor NMI, Manolaridis I, Jackson SM, Kowal J, Stahlberg Henning, Locher Kaspar “Structure of the human multidrug transporter ABCG2“ Nature (2017) [Press release]

• Bindocci E, Savtchouk I, Liaudet N, Becker D, Carriero G, Volterra Andrea “Three-dimensional Ca(2+) imaging advances understanding of astrocyte biology“ Science (2017)

• Ferreira-Gomes M, Montalbetti N, Simonin A, Strehler EE, Rossi JP, Hediger M “Cortical cytoskeleton dynamics regulates plasma membrane calcium ATPase isoform-2 (PMCA2) activity“ Biochim Biophys Acta (2017)

• Lüscher B, Marini C, Joerger-Messerlia M, Huang X, Albrecht Christiane, , Surbek D, Hediger M “Placental glucose transporter (GLUT)-1 is down-regulated in preeclampsia“ Placenta (2017)

• Awale M, Probst D, Reymond Jean-Louis “WebMolCS: A Web-Based Interface for Visualizing Molecules in Three-Dimensional Chemical Spaces“ J Chem Inf Model (2017)

• ElMokh, O, Ruffieux-Daidié, D., Roelli, M, Stooss, A, Phillips, W. A, Dettmer, M. S, Gertsch Jürg, “Combined MEK and Pi3'-kinase inhibition reveals synergy in targeting thyroid cancer in vitro and in vivo“ Oncotarget (2017)

• Mahdi ZM, Stieger B “Model Systems for Studying the Role of Canalicular Efflux Transporters in Drug-Induced Cholestatic Liver Disease“ J Pharm Sci (2017)

• Langron E, Simone MI, Delalande C, Reymond Jean-Louis, Selwood DL , Vergani P “Improved fluorescence assays to measure the defects associated with F508del-CFTR allow identification of new active compounds“ Br J Pharmacol (2017)

• Biyani N, Righetto R, McLeod R, Caujolle-Bert D, Castano-Diez D, Goldie K, Stahlberg Henning “Focus: The interface between data collection and data processing in cryo-EM“ J. Struct. Biol. (2017)

• Buscemi L, Ginet V, Lopatar J, Montana V, Pucci L, Spagnuolo P, Zehnder T, Grubišic V, Truttman A, Sala C, Hirt L, Parpura V, Puyal J, Bezzi P “Homer1 Scaffold Proteins Govern Ca2+ Dynamics in Normal and Reactive Astrocytes“ Cereb Cortex (2017)

• Awale M, Reymond Jean-Louis “The polypharmacology browser: a web-based multi-fingerprint target prediction tool using ChEMBL bioactivity data“ J Cheminform (2017)

• Chicca A, Berg R, Jessen HJ, Jessen HJ, Schmid F, Burch P, Gertsch Jürg “Biological evaluation of pyridone alkaloids on the endocannabinoid system“ Bioorg Med Chem (2017)

• Albano G, Dolder S, Siegrist M, Mercier-Zuber A, Auberson M, Stoudmann C, Bonny O, Fuster Daniel, Hofstetter W “Increased bone resorption by osteoclast-specific deletion of the sodium/calcium exchanger isoform 1 (NCX1)“ Pflugers Arch. (2017)

• , Polyhach Y, Eichmann C, Chi CN, Kowal J, Albiez S, McLeod R, Stahlberg Henning, Jeschke G, Günter P, Riek R “Solution structure of discoidal high-density lipoprotein particles with a shortened apolipoprotein A-I“ Nature Structural and Molecular Biology (2017)

• Sejwal K, Chami M, Baumgartner P, Kowal J, Müller SA , Stahlberg Henning “Proteoliposomes - a system to study membrane proteins under buffer gradients by cryo-EM“ Nanotechnology Reviews (2017)

• Gachet MS, Schubert A, Calarco S, Boccard J, Gertsch Jürg “Targeted metabolomics shows plasticity in the evolution of signaling lipids and uncovers old and new endocannabinoids in the plant kingdom“ Nature Science Reports (2017)

• Ernsthofer IA, Manatschal C, Arnold FM, Laederach J, Dutzler Raimund “Structural and mechanistic basis of proton-coupled metal ion transport in the SLC11/NRAMP family“ Nature Comm. (2017)

• Mahdi ZM , Jäger W, Stieger B “Intestinal and Hepatocellular Transporters: Therapeutic Effects and Drug Interactions of Herbal Supplements“ Annu Rev Pharmacol Toxicol (2017)

• Ontsouka CE, Huang X, Aliyev E, Albrecht Christiane “In vitro characterization and endocrine regulation of cholesterol and phospholipid transport in the mammary gland“ Mol Cell Endocrinol (2017)

• Soethoudt M, et al, Gertsch Jürg, et al “Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity.“ Nat Commun (2017)

• Wnuk M, Anderegg MA, Graber WA, Buergy R, Fuster Daniel, Djonov V “Neuropilin1 regulates glomerular function and basement membrane composition through pericytes in the mouse kidney “ Kidney Int. (2016)

• Hagenbuch B, Stieger B “Recent advances in understanding hepatic drug transport“ F1000Res (2016)

• Deisl C, Anderegg M, Albano G, Lüscher BP, Cerny D, Soria R, Bouillet E, Rimoldi S, Scherrer U, Fuster Daniel “Loss of Sodium/Hydrogen Exchanger NHA2 Exacerbates Obesity- and Aging-Induced Glucose Intolerance in Mice“ PLoS One (2016)

• Bürgi JJ, Bertrand S, Marger F, Bertrand D, Reymond Jean-Louis “Fluorescent Agonists of the α7 Nicotinic Acetylcholine Receptor Derived from 3-Amino-Quinuclidine“ Helvetica Chimica Acta (2016)

• Dhayat NA, Ackermann D, Pruijm M, Ponte B, Ehret G, Guessous I, Leichtle AB, Paccaud F, Mohaupt M, Fiedler GM, Devuyst O, Pechère-Bertschi A, Burnier M, Martin PY, Vogt B, Bochud Murielle, Fuster Daniel “Fibroblast growth factor 23 and markers of mineral metabolism in individuals with preserved renal function“ Kidney Int. (2016)

• Clémençon B, Fine M, Hediger M “Conservation of the oligomeric state of native VDAC1 in detergent micelles “ Biochimie (2016)

• Ilgü H, Jeckelmann J-M, Gapsys V, Ucurum Z, de Groot BL, Fotiadis Dimitrios “Insights into the molecular basis for substrate binding and specificity of the wild-type L-arginine/agmatine antiporter AdiC“ PNAS (2016) [Press release]

• Kilchmann F, Marcaida MJ, Kotak S, Schick T, Boss SD, Awale M, Gönczy P , Reymond Jean-Louis “Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening“ J. Med. Chem. (2016)

• Bariselli S, Tzanoulinou S, Glangetas C, Prévost-Solié C, Pucci L, Viguié J, O'Connor E, Georges F, Lüscher C, , Bezzi P “SHANK3 controls maturation of social reward circuits in the VTA“ Nat Neurosci (2016)

• Mahdi ZM, Synal-Hermanns U, Yoker A, Locher Kaspar, Stieger B “Role of Multidrug Resistance Protein 3 (MDR3) in Antifungal-Induced Cholestasis.“ Mol Pharmacol (2016)

• Bertini S, Chicca A, Arena C, Chicca S, Saccomanni G, Gertsch Jürg, Manera C, Macchia M “Synthesis and pharmacological evaluation of new biphenylic derivatives as CB2 receptor ligands“ Eur J Med Chem (2016)

• Pantelic RS, Meyer JC, Kaiser U, Stahlberg Henning “The application of Graphene as a sample support in Transmission Electron Microscopy“ Solid State Communications (2016)

• Boggavarapu R, Hirschi S, Harder D, Meury M, Ucurum Z, Bergeron MJ, Fotiadis Dimitrios “Purification of human and mammalian membrane proteins expressed in Xenopus laevis frog oocytes for structural studies“ Methods Mol Biol (2016)

• O. Wellnitz, C. Zbinden, X. Huang, R.M. Bruckmaier “Differential loss of bovine mammary epithelial barrier integrity in response to lipopolysaccharide and lipoteichoic acid“ J Dairy Sci (2016)

• Rau M, Nicolussi S, Gertsch Jürg, Chicca A “Assay of Endocannabinoid Uptake“ Methods Mol Biol (2016)

• Albrecht Christiane, Ontsouka EC, Bruckmeier RM “ Growth-promoting effects of colostrum in calves based on interaction with intestinal cell surface receptors and receptor-like transporters“ J. Dairy Sci. (2016)

• Syam N, Chatel S, Ozhathil LC, Sottas V, Rougier JS, Baruteau A, Baron E, Amarouch MY, Daumy X, Probst V, Schott JJ, Abriel Hugues “Variants of Transient Receptor Potential Melastatin Member 4 in Childhood Atrioventricular Block“ J Am Heart Assoc (2016)

• Awale M, Reymond Jean-Louis “Web-based 3D-visualization of the DrugBank chemical space“ J. Cheminform (2016)

• Dhayat N, Simonin A, Anderegg M, Pathare G, Lüscher BP, Deisl C, Albano G, Mordasini D, Vogt B, Sass JO, Kloeckener-Gruissem B, Fuster Daniel, Hediger M, Surbek D “Mutation in the Monocarboxylate Transporter 12 Gene Affects Guanidinoacetate Excretion but Does Not Cause Glucosuria.“ J Am Soc Nephrol. (2016)

• Dhayat N, Schaller A, Albano A, Poindexter J, Griffith C, Pasch A, Gallati S, , Moe OW, Fuster Daniel “The vacuolar H+-ATPase B1 subunit polymorphism p.E161K is associated with impaired urinary acidification in recurrent stone formers.“ J Am Soc Nephrol. (2016)

• Oláh A, Ambrus L, Nicolussi S, Gertsch Jürg, Tubak V, Kemény L, Soeberdt M, Abels C, Bíró T “Inhibition of fatty acid amide hydrolase exerts cutaneous anti-inflammatory effects both in vitro and in vivo“ Exp Dermatol (2016)

• Gross JJ, Schwinn A.-C, Schmitz-Hsu F, Menzi F, Drögemüller C, Albrecht Christiane, Bruckmaier RM “Cholesterol deficiency associated APOB mutation impacts lipid metabolism in Holstein calves and breeding bulls“ J Anim Sci (2016)

• Eisele N, Albrecht Christiane, Mistrya HD, Dicka B, Baumann M, Currie G, Delles C, Mohaupta MG, Eschera G, Gennari-Moser C, Surbek D “Placental expression of the angiogenic placental growth factor is stimulated by both aldosterone and simulated starvation“ Placenta (2016)

• Xie W, Dolder S, Siegrist M, Wetterwald A, Hofstetter W “Glutamate Receptor Agonists and Glutamate Transporter Antagonists Regulate Differentiation of Osteoblast Lineage Cells“ Calcif Tissue Int (2016)

• Daumy X, Amarouch MY, Lindenbaum P, Bonnaud S, Charpentier E, Bianchi B, Nafzger S, Baron E, Fouchard S, Thollet A, Kyndt F, Barc J, Le Scouarnec S, Makita N, Le Marec H, Dina C, Gourraud JB, Probst V, Abriel Hugues, Redon R, Schott JJ “Targeted resequencing identifies TRPM4 as a major gene predisposing to progressive familial heart block type I“ International Journal of Cardiology (2016)

• Xie W, Lorenz S, Dolder S, Hofstetter W “Extracellular Iron is a Modulator of the Differentiation of Osteoclast Lineage Cells“ Calcif Tissue Int (2016)

• Huang X, Lüthi M, Ontsouka EC, Kallol S, Baumann MU, Albrecht Christiane, Surbek D “Establishment of a confluent monolayer model with human primary trophoblast cells: novel insights into placental glucose transport“ Mol Hum Reprod (2016)

• Leuenberger M, Ritler A, Simonin A, Lochner Martin, Hediger M “Concise Asymmetric Synthesis and Pharmacological Characterization of All Stereoisomers of Glutamate Transporter Inhibitor TFB-TBOA and Synthesis of EAAT Photoaffinity Probes“ ACS Chem. Neurosci. (2016)

• Gachet MS, Gertsch Jürg “N-acylethanolamines and steroids in biological samples by LCMS/MS: Fit to purpose“ J Chromatogr B Analyt Technol Biomed Life Sci (2016)

• Petrelli F, Pucci L, Bezzi P “Astrocytes and Microglia and Their Potential Link with Autism Spectrum Disorders“ Front Cell Neurosci. (2016)

• Knight A, Hemmings JL, Winfield I, Leuenberger M, Frattini E, Frenguelli BG, Dowell SJ, Lochner Martin, Ladds G “Discovery of Novel Adenosine Receptor Agonists that Exhibit Subtype Selectivity“ J Med Chem (2016)

• Petrelli F, Bezzi P “Novel insights into gliotransmitters“ Curr Opin Pharmacol (2016)

• Ayciriex S, Gerber H, Osuna GM, Chami M, Stahlberg Henning, Shevchenko A, Fraering PC “The lipidome associated with the gamma-secretase complex is required for its integrity and activity“ Biochemical Journal (2016)

• Albrecht Christiane, Ontsouka EC, Bertschi JS, Huang X, Lüthi M, Müller S “Can widely used cell type markers predict the suitability of immortalized or primary mammary epithelial cell models?“ Biol Res (2016)

• Albrecht Christiane, Caniggia I, Clifton V, Göhner C, Harris L, Hemmings D, Jawerbaum A, Johnstone E, Jones H, Keelan J, Lewis R, Mitchell M, Murthi P, Powell T, Saffery R, Smith R, Vaillancourt C, Wadsack C, Salomon C “IFPA meeting 2015 workshop report IV: Nanomedicine applications and exosome biology, xenobiotics and endocrine disruptors and pregnancy, and lipid mediators and placental function“ Placenta (2016)

• Kudryashev M, Castano-Diez D, Deluz C, Hassaine G, Grasso L, Graff A, Vogel H, Stahlberg Henning “The structure of the mouse serotonin 5-HT3 receptor in lipid vesicles.“ Structure (2016)

• Montanari F, Pinto M, Khunweeraphong N, Wlcek K, Sohail MI, Noeske T, Boyer S, Chiba P, Kuchler K, Ecker GF, Stieger B “Flagging drugs that inhibit the bile salt export pump“ Mol Pharm (2016)

• Simonin A, Montalbetti N, Gyimesi G, Pujol-Giménez J, Hediger M “The Hydroxyl Side Chain of a Highly Conserved Serine Residue Is Required for Cation Selectivity and Substrate Transport in the Glial Glutamate Transporter GLT-1/SLC1A2“ J Biol Chem (2015)

• Habbas S, Santello M, Becker D, Stubbe H, Zappia G, Liaudet N, Klaus FR, Kollias G, Fontana A, Pryce CR, Suter T, Volterra Andrea “Neuroinflammatory TNFα Impairs Memory via Astrocyte Signaling“ Cell (2015) [Press release]

• Sultan S, Li L, Moss J, Petrelli F, Cassé F, Gebara E, Lopatar J, Pfrieger FW, Bezzi P, Bischofberger J, Toni N “ Synaptic Integration of Adult-Born Hippocampal Neurons Is Locally Controlled by Astrocytes.“ Neuron (2015)

• Simonin C, Awale M, Brand M, van Deursen R, Schwartz J, Fine M, Kovacs G, Häfliger P, Gyimesi G, Sithampari A, , Hediger M, Reymond Jean-Louis “Optimization of TRPV6 Calcium Channel Inhibitors Using a 3D Ligand-Based Virtual Screening Method“ Angew. Chem. (2015)

• Looser V, Brühlmann B, Bumbak F, Stenger C, Costa M, Camattari A, Fotiadis Dimitrios, Kovar K “Cultivation strategies to enhance productivity of Pichia pastoris: A review“ Biotechnol Adv. (2015)

• Stahlberg Henning, Biyani N, Engel A “3D reconstruction of two-dimensional crystals“ Arch Biochem Biophys (2015)

• Reymond Jean-Louis, Awale M “Similarity mapplet: Interactive visualization of the directory of useful decoys and ChEMBL in high dimensional chemical spaces“ J Chem Inf Model (2015)

• Boggavarapu R, Jeckelmann JM, Harder D, Ucurum Z, Fotiadis Dimitrios “Role of electrostatic interactions for ligand recognition and specificity of peptide transporters“ BMC Biol. (2015)

• Damseh N, Simonin A, Jalas C, Picoraro JA, Shaag A, Cho MT, Yaacov B, Juusola J, Al-Ashhab M, Bale S, Telegrafi A, Retterer K, Pappas JG, Cappell J, Yeboa KA, Abu-Libdeh B, Hediger M, Chung WK, Elpeleg O, Edvardson S “Mutations in SLC1A4, encoding the brain serine transporter, associated with developmental delay, microcephaly and hypomyelination“ J Med Genet (2015)

• Montalbetti N, Simonin A, Simonin C, Awale M, Reymond Jean-Louis, Hediger M “Discovery and characterization of a novel non-competitive inhibitor of the divalent metal transporter DMT1/SLC11A2“ Biochem Pharmacol (2015)

• Cesar-Razquin A, Snijder B, Frappier-Brinton T, Isserlin R, Gyimesi G, Bai X, Reithmeier RA, Hepworth D, Hediger M, Edwards AM, Superti-Furga G “A Call for systematic research on solute carriers“ Cell (2015) [Press release]

• Fotiadis Dimitrios, Engel A “Two-dimensional crystallization of membrane proteins and structural assessment“ eLS (2015)

• Albrecht Christiane, Gross JJ, Kessler EC “Response of the cholesterol metabolism to a negative energy balance in dairy cows depends on the lactational stage“ PLoS One (2015)

• Reymond Jean-Louis, Gonzalez-Salgado A, Steinmann M, Major LL, Sigel E, Smith TK, Butikofer P “Trypanosoma brucei bloodstream forms depend upon uptake of myo-inositol for Golgi complex phosphatidylinositol synthesis and normal cell growth“ Eukaryot Cell (2015)

• Chicca A, Gachet MS, Petrucci V, Schuehly W, , Gertsch Jürg “4’-O-Methylhonokiol increases levels of endocannabinoids in mouse brain via selective inhibition of their COX-2-mediated oxygenation“ J Neuroinflamm. (2015)

• Albano G, Moor M, Dolder S, Siegrist M, Wagner CA, Biber J, Hernando N, Bonny W, Fuster Daniel, Hofstetter W “Sodium dependent phosphate transporters in osteoclast differentiation and function“ PLoS One (2015)

• Del Carlo S, Manera C, Chicca A, Arena C, Bertini S, Burgalassi S, Tampuccia S, Gertsch Jürg, Macchia M, Saccomanni G “Development of an HPLC/UV assay for the evaluation of inhibitors of human recombinant monoacylglycerol lipase“ Pharm Biomed Anal (2015)

• Patsenker E, Sachse P, Chicca A, Gachet MS, Schneider V, Mattsson J, Lanz C, Worni M, de Gottardi A, Semmo M, Hampe J, Schafmayer C, Brenneisen R, Gertsch Jürg, Stickel F, Semmo N “ Elevated levels of endocannabinoids in chronic hepatitis C may modulate cellular immune response and hepatic stellate cell activation“ Int J Mol Sci (2015)

• Clémençon B, Fine M, Schneider P, Hediger M “Rapid method to express and purify human membrane protein using the Xenopus oocyte system for functional and low-resolution structural analysis“ Method Enzymol (2015)

• Gao B, Stieger B “Drug transporters in the central nervous system“ Clin Pharmacokinet (2015)

• Nicolussi S, Gertsch Jürg “Endocannabinoid transport revisited“ Vitam Horm (2015)

• Reymond Jean-Louis, Awale M, Jin X1 “Stereoselective virtual screening of the ZINC database using atom pair 3D-fingerprints“ Cheminform. (2015)

• Bosshart P, Engel A, Fotiadis Dimitrios “High-resolution atomic force microscopy imaging of rhodopsin in rod outer segment disk membranes“ Methods Mol Biol. (2015)

• Gachet MS, Rhyn P, Bosch OG, Quednow BB, Gertsch Jürg “A quantitiative LC-MS/MS method for the measurement of arachidonic acid, prostanoids, endocannabinoids, N-acylethanolamines and steroids in human plasma“ J Chromatogr B Analyt Technol Biomed Life Sci. (2015)

• Baruteau AE, Probst V, Abriel Hugues “Inherited progressive cardiac conduction disorders“ Curr Opin Cardiol (2015)

• Nicolussi S, Chicca A, Rau M, Rihs S, Soeberdt M, Abels C, Gertsch Jürg “Correlating FAAH and anandamide cellular uptake inhibition using N-alkylcarbamate inhibitors: from ultrapotent to hyperpotent, Biochem Pharmacol“ Biochem Pharmacol (2014)

• Brunner JD, Lim NK, Schenck S, Duerst A, Dutzler Raimund “X-ray structure of a calcium-activated TMEM16 lipid scramblase“ Nature (2014)

• Unadkat JD, Prasad B, Langer O, Gali H, Stieger B “Role of (drug) transporters in imaging in health and disease“ Drug Metab Dispos (2014)

• Ehrnstorfer IA, Geertsma ER, Pardon E, Steyaert J, Dutzler Raimund “Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transport“ Nat Struct Biol. (2014)

• Zhang J, Fuster Daniel, Cameron MA, Quiñones H, Griffith C, Xie XS, Moe OW “ Incomplete distal renal tubular acidosis from a heterozygous mutation of the V-ATPase B1 subunit“ Am J Physiol Renal Physiol. (2014)

• Chevalier M, Amuzescu B, Gawali V, Todt H, Knott T, Scheel O, Abriel Hugues “Late cardiac sodium current can be assessed using automated patch-clamp“ F1000Res (2014)

• Kudryashev M, Aktoudianaki A, Dedoglou D, Stahlberg Henning, Tsiotis G “The ultrastructure of Chlorobaculum tepidum revealed by cryo electron tomography“ Biochim Biophys Acta (2014)

• Meury M, Costa M, Harder D, Stauffer M, Jeckelmann J-M, Brühlmann B, Rosell A, Ilgü H, Kovar K, Palacín M, Fotiadis Dimitrios “Detergent-induced stabilization and improved 3D map of the human heteromeric amino acid transporter 4F2hc-LAT2“ PLoS One (2014)

• Rosati O, Messina F, Pelosi A, Curini M, Petrucci V, Gertsch Jürg, Chicca A “One-pot heterogeneous synthesis of Δ(3)-tetrahydrocannabinol analogues and xanthenes showing differential binding to CB(1) and CB(2) receptors“ Eur J Med Chem (2014)

• Clémençon B, Lüscher BP, Fine M, Baumann MU, Surbek D, Bonny O, Hediger M “Expression, purification and structural insights of the human uric acid transporter GLUT9 using the Xenopus laevis oocytes system“ PLoS One (2014)

• Jeckelmann J‐M, Harder D, Ucurum Z, Fotiadis Dimitrios “2D and 3D crystallization of a bacterial membrane protein homologue of human vitamin C transporters“ J Struct Biol. (2014)

• Albrecht Christiane, Dumusc SD, Ontsouka EC, Schnyder M, Hartnack-Wilhelm S, Bruckmaier RM, Burgener IA “Cyclooxygenase-2 and 5-Lipoxygenase in dogs with chronic enteropathies“ J Vet Intern Med. (2014)

• Kessler EC, Gross JJ, Bruckmaier RM, Albrecht Christiane “Cholesterol metabolism, transport, and hepatic regulation in dairy cows during transition and early lactation“ J Dairy Sci (2014)

• Awale M, Reymond Jean-Louis “Atom pair 2D-fingerprints perceive 3D-molecular shape and pharmacophores for very fast virtual screening of ZINC and GDB-17“ J Chem Inf Model (2014)

• Hajdu Z, Nicolussi S, Rau M, Lorántfy L, Forgo P, Hohmann J, Csupor D, Gertsch Jürg “Identification of endocannabinoid system modulating N-alkylamides from Heliopsis helianthoides var. scabra and Lepidium meyenii“ J Nat Prod (2014)

• Chicca A, Caprioglio D, Minassi A, Petrucci V, Appendino G, Taglialatela-Scafati O, Gertsch Jürg “Functionalization of β-caryophyllene generates novel polypharmacology in the endocannabinoid system“ ACS Chem Biol (2014)

• Franz MC, Simonin A, Graeter S, Hediger M, Kovacs G, “Development of the first fluoerescence screening assay for SLC39A2 zinc transporter“ J Biomol Screen (2014)

• Awale M, Reymond Jean-Louis “A multi-fingerprint browser for the ZINC database“ Nucleic Acids Res (2014)

• Montalbetti N, Simonin A, Dalghi MG, Kovács G, Hediger M “Development and validation of a fast and homogeneous cell-based fluorescence screening assay for divalent metal transporter-1 (DMT1/SLC11A2) using the FLIPR tetra“ J Biomol Screen (2014)

• Deisl C, Albano G, Fuster Daniel “Role of Na/H exchange in insulin secretion by islet cells“ Curr Opin Nephrol Hypertens (2014)

• Albrecht Christiane, Jain A, Schneider H, Aliyev E, Soydemir F, Baumann M, Brownbill P, Hediger M, Surbek D “Hypoxic treatment of human dual placental perfusion induces a pre-eclampsia-like inflammatory response“ Laboratory Invest. (2014)

• Guyot C, Hofstetter L, Stieger B “ Differential effects of membrane cholesterol content on the transport activity of multidrug resistance-associated protein 2 (ABCC2) and of the bile salt export pump (ABCB11)“ Mol Pharmacol (2014)

• Ruddigkeit L, Awale M, Reymond Jean-Louis “Expanding the fragrance chemical space for virtual screening“ J Cheminform (2014)

• Bürgi J, Awale M, Boss S, Schaer T, Marger F, Viveros-Paredes J, Bertrand S, Gertsch Jürg, Bertrand D, Reymond Jean-Louis “Discovery of potent positive allosteric modulators of the α3β2 nicotinic acetylcholine receptor by a chemical space walk in ChEMBL“ ACS Chem Neurosci (2014)

• Volterra Andrea, , Savchouk I “Astrocyte Ca2+signaling: an unexpected complexity“ Nat Rev Neurosci (2014)

• Scherer S, Kowal J, Chami M, Dandey V, Arheit M, Ringler P, Stahlberg Henning “2dx_automator: Implementation of a semiautomatic high-throughput high-resolution cryo-electron crystallography pipeline“ J Struct Biol (2014)

• Ilgü H, Jeckelmann J-M, Gachet SM, Boggavarapu R, Ucurum Z, Gertsch Jürg, Fotiadis Dimitrios “Variation of the detergent-binding capacity and phospholipid content of membrane proteins when purified in different detergents“ Biophys J (2014)

• McCoy JG, Rusinova R, Kim D, Kowal J, Banerjee S, Thompson AN, Kolmakova-Partensky L, Stahlberg Henning, Andersen OS, Nimigean CM “A KcsA/MloK1 chimeric ion channel has lipid-dependent ligand binding energetics“ J Biol Chem (2014)

• Abriel Hugues, Clémençon B, Fine M, Lüscher B, Baumann MU, Hediger M, Surbek D “Expression, purification, and projection structure by single particle electron microscopy of functional human TRPM4 heterologously expressed in Xenopus laevis oocytes“ Protein Expr Purif. (2014)

• Montalbetti N, Dalghi MG, Albrecht Christiane, Hediger M “Nutrient transport in the mammary gland: calcium, trace minerals and water soluble vitamins“ Biol Neoplasia (2014)

• Wlcek K, Hofstetter L, Stieger B “Transport of estradiol-17b-glucuronide, estrone-3-sulfate and taurocholate across the endoplasmic reticulum membrane: evidence for different transport systems,“ Biochem Pharmacol (2014)

• Wlcek K, Stieger B “ATP-binding cassette transporters in liver“ Biofactors (2014)

• Scherer S, Arheit M, Kowal J, Zeng X, Stahlberg Henning “Single particle 3D reconstruction for 2D crystal images of membrane proteins“ J Struct Biol (2014)

• Ontsouka EC, Albrecht Christiane “Cholesterol transport and regulation in the mammary gland“ J Mammary Gland Biol Neoplasia (2014)

• Abriel Hugues, Syam N, Rougier JS “Glycosylation of TRPM4 and TRPM5 channels: molecular determinants and functional aspects“ Front Cell Neurosci. (2014)

• Schwan C, Kruppke AS, Nölke T, Kudryashev M, Stahlberg Henning, Aktories K “Clostridium difficile toxin CDT hijacks microtubule organization and re-routes vesicle traffic to increase pathogen adherence“ Proc Natl Acad Sci USA (2014)

• Nicolussi S, Viveros-Paredes JM, Gachet MS, Rau M, Flores-Soto ME, Blunder M, Gertsch Jürg “Guineensine is a novel inhibitor of endocannabinoid uptake showing cannabimimetic behavioral effects in BALB/c mice“ Pharmacol Res (2014)

• Albrecht Christiane, Abumaree MH, Alahari S, Aye IL, Bainbridge S, Chauvin S, Clifton VL, Desoye G, Ermini L, Giuffrida D, Graham CH, Huang QT, Kalionis B, Lager S, Leech L, Li Y, Litvack ML, Nuzzo AM, Moretto-Zita M, O'Tierney-Ginn P, Powell T, Rolfo A, Salomon C, Serov A, Westwood M, Yung HW, Lash GE “Diabetes in pregnancy, maternal dyslipidemia in pregnancy, oxygen in placental development, stem cells and pregnancy pathology“ Placenta. (2014)

• Kowal J, Chami M, Baumgartner P, Arheit M, Chiu P-L, Schröder GF, Nimigean CM, Stahlberg Henning “ Ligand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1“ Nat Commun (2014)

• Kouri T, Awale M, Slyby J, Reymond Jean-Louis, Mehta D “A "social" network of isomers based on bond count distance: algorithms“ J Chem Inf Model (2014)

• Rosell A, Meury M, Alvarez-Marimon E, Costa M, Pérez-Cano L, Zorzano A, Fernández-Recio J, Palacín M, Fotiadis Dimitrios “Structural bases for the interaction and stabilization of the human amino acid transporter LAT2 with its ancillary protein 4F2hc“ Proc Natl Acad Sci USA (2014)

• Hagenbuch B, Stieger B “Organic anion transporting polypeptides“ Curr Top Membr (2014)

• Fuster Daniel, Alexander RT, “Traditional and emerging roles for the SLC9 Na+/H+ exchangers“ Pflugers Arch. (2014)

• Burch P, Chicca A, Gertsch Jürg, Gademann K “Functionally optimized neuritogenic farinosone C analogs: SAR-study and investigations on their mode of action“ ACS Med Chem Lett (2013)

• Rexhaj E, Paoloni-Giacobino A, Rimoldi SF, Fuster Daniel, Anderegg M, Somm E, Bouillet E, Allemann Y, Sartori C, Scherrer U “Mice generated by in vitro fertilization exhibit vascular dysfunction and shortened life span“ J Clin Invest. (2013)

• Baumann M, Körner M, Huang X, Wenger F, Surbek D, Albrecht Christiane “Placental ABCA1 and ABCG1 expression in gestational disease: pre-eclampsia affects ABCA1 levels in syncytiotrophoblasts“ Placenta (2013)

• Boggavarapu R, Jeckelmann J-M, Harder D, Schneider P, Ucurum Z, Fotiadis Dimitrios, Hediger M “Expression, purification and low-resolution structure of human vitamin C transporter SVCT1 (SLC23A1)“ PLoS One (2013)

• Kovács G, Montalbetti N, Franz MC, Graeter S, Simonin A, Hediger M “Human TRPV5 and TRPV6: key players in cadmium and zinc toxicity“ Cell Calcium (2013)

• Degiacomi MT, Iacovache I, Pernot L, Chami M, Kudryashev M, Stahlberg Henning, van der Goot FG, Dal Peraro M “The molecular assembly of the aerolysin pore reveals a swirling membrane-insertion mechanism“ Nat Chem Biol (2013)

• Schwartz J, Awale M, Reymond Jean-Louis “SMIfp (SMILES fingerprint) chemical space for virtual screening and visualization of large databases of organic molecules“ J Chem Inf Model (2013)

• Balázs B, Dankó T, Kovács G, Köles L, Hediger M, Zsembery Á “ Investigation of the inhibitory effects of the benzodiazepine derivative, 5-BDBD on P2X4 purinergic receptors by two complementary methods“ Cell Physiol Biochem (2013)

• Ontsouka EC, Huang X, Albrecht Christiane, Stieger B “Characteristics and functional relevance of apolipoprotein-A1 and cholesterol binding in mammary gland tissues and epithelial cells“ PLoS One (2013)

• Kudryashev M, Stenta M, Schmelz S, Amstutz M, Wiesand U, Castaño-Díez D, Degiacomi MT, Münnich S, Bleck CK, , Diepold A, Heinz DW, Dal Peraro M, Cornelis GR, Stahlberg Henning “ In situ structural analysis of the Yersinia enterocolitica injectisome“ eLife (2013)

• , Kebbel F, Arheit M, Grütter MG, Stahlberg Henning, Kurz M “Structure and substrate induced conformational changes of the secondary citrate/sodium symporter CitS by electron crystallography“ Structure (2013)

• Huang X, Nikitina L, Wenger F, Körner M, Albrecht Christiane, Surbek D “RNA degradation differentially affects quantitative mRNA measurements of endogenous reference genes in human placenta“ Placenta (2013)

• “Maternal cholestasis during pregnancy programs metabolic disease in offspring“ J Clin Invest (2013)

• Deisl C, Simonin A,, Anderegg M, Albano G, Kovacs G, Ackermann D, Moch H, Dolci W, Thorens B, Hediger M, Fuster Daniel “Sodium/hydrogen exchanger NHA2 is critical for insulin secretion in β-cells“ Proc Natl Acad Sci USA (2013)

• Hofer A, Kovacs G, Zappatini A, Leuenberger M, Hediger M, Lochner Martin “Design, synthesis and pharmacological characterization of analogs of 2-aminoethyl diphenylborinate (2-APB), a known store-operated calcium channel blocker, for inhibition of TRPV6-mediated caclium transport“ Bioorg Med Chem (2013)

• Abriel Hugues, Amarouch MY, Syam N “Biochemical, single-channel, whole-cell patch clamp, and pharmacological analyses of endogenous TRPM4 channels in HEK293 cells“ Neuroscience Letters (2013)

• Fotiadis Dimitrios, Kanai Y, Palacin M “The SLC3 and SLC7 families of amino acid transporters“ Mol Asp Med (2013)

• Bodoy S, Fotiadis Dimitrios, Stoeger C, Kanai Y, Palacín M “The small SLC43 family: facilitator system L amino acid transporters and the orphan EEG1“ Mol Aspects Med. (2013)

• Bergeron MJ, Clémençon B, Hediger M, Markovich D “SLC13 family of Na+-coupled di- and tricarboxylate/sulfate transporters“ Mol Aspects Med (2013)

• Bürzle M, Suzuki Y, Ackermann D, Miyazaki H, Maeda N, Clémençon B, Burrier R, Hediger M “The sodium-dependent ascorbic acid transporter family SLC23“ Mol Aspects Med (2013)

• El-Gebali S, Bentz S, Hediger M, Anderle P “Solute carriers (SLCs) in cancer“ Mol Aspects Med (2013)

• Franz MC, Anderle P, Freeman M, Suzuki Y, Hediger M, Kovács G “Zinc transporters in prostate cancer“ Mol Aspects Med (2013)

• Smith DE, Clemencon B, Hediger M “Proton-coupled oligopeptide transporter family SLC15: physiological, pharmacological and pathological implications“ Mol Aspects Med (2013)

• Kanai Y, Clémençon B, Simonin A, Leuenberger M, Lochner Martin, Weisstanner M, Hediger M “The SLC1 high-affinity glutamate and neutral amino acid transporter family“ Mol Aspects Med (2013)

• Hagenbuch B, Stieger B “The SLCO (former SLC21) superfamily of transporters“ (2013)

• Donowitz M, Tse CM, Fuster Daniel “SLC9 or NHE gene family, a plasma membrane and organellar family of Na+/H+ antiporters“ Mol Asp Med (JMAM) (2013)

• Awale M, van Deursen R, Reymond Jean-Louis “The MQN-Mapplet: Visualization of chemical space with interactive maps of DrugBank, ChEMBL, PubChem, GDB-11 and GDB-13“ J Chem Inf Model (2013)

• Huang X, Jain A, Baumann M, Körner M, Bütikofer P, Albrecht Christiane, Surbek D “ Increased placental lipid levels in pre-eclamptic pregnancies“ Int J Mol Sci (2013)

• Abriel Hugues, Liu H, Chatel S, Simard C, Syam N, Salle L, Probst V, Morel J, Millat G, Lopez M, Schott JJ, Guinamard R, Bouvagnet P “Molecular genetics and functional anomalies in a series of 248 Brugada cases with 11 mutations in the TRPM4 channel“ PLoS ONE (2013)

• Costa M, Rosell A, Alvarez-Marimon E, Zorzano A, Fotiadis Dimitrios, Palacín M “Expression of human heteromeric amino acid transporters in the yeast Pichia pastoris“ Protein Expr Purif. (2013)

• De Pittà M, Volman V, Berry H, Parpura V, Volterra Andrea, Ben Jacob E “Computational quest for understanding the role of astrocyte signalling in synaptic transmission and plasticity“ Front Comput Neurosci (2012)

• Chicca A,, Marazzi J, Gertsch Jürg “ The antinociceptive triterpene β-amyrin inhibits 2-arachidonoylglycerol (2-AG) hydrolysis without directly targeting CB receptors“ British Journal of Pharmacology (2012)

• Kovács G, Montalbetti N, Simonin A, Danko T, Balazs B, Zsembery A, Hediger M “Inhibition of the human epithelial calcium channel TRPV6 by 2-aminoethoxydiphenyl borate (2-APB)“ Cell Calcium (2012)

• Fotiadis Dimitrios, Müller DJ “High-resolution imaging of 2D outer membrane protein F (OmpF) crystals by atomic force microscopy“ Methods Mol Biol. (2012)

• Chicca A, Marazzi J, Nicolussi S, Gertsch Jürg “Evidence for bidirectional endocannabinoid transport across cell membranes“ Journal of Biological Chemistry (2012)

• Abriel Hugues, Syam N, Sottas V, Amarouch MY, Rougier JS “TRPM4 channels in the cardiovascular system: physiology, pathophysiology, and pharmacology“ Biochem Pharmacol (2012)

• Santello M, Volterra Andrea “TNFalpha in synaptic transmission: switching gears“ Trends Neurosci (2012)

• Reymond Jean-Louis, Awale M “Exploring chemical space for drug discovery using the chemical universe database“ ACS Chem Neurosci (2012)

• Awale M, Reymond Jean-Louis “Cluster analysis of the DrugBank chemical space using molecular quantum numbers“ Bioorg Med Chem (2012)

• Hilge M “Ca2+ regulation of ion transport in the Na+/Ca2+ exchanger“ J Biol Chem (2012)

• Harder D, Fotiadis Dimitrios “Measuring substrate binding and affinity of purified membrane transport proteins using the scintillation proximity assay“ Nature Protocols (2012)

• Moidunny S, Vinet J, Wesseling E, Bijzet J, Shieh CH, van Ijzendoorn SC, Bezzi P, Boddeke HW, Biber K “ Adenosine A(2B) receptor-mediated leukemia inhibitory factor release from astrocytes protects cortical neurons against excitotoxicity“ Neuroinflammation (2012)

• Fotiadis Dimitrios “Atomic force microscopy for the study of membrane proteins“ Curr Opin Biotechnol. (2012)

• Casuso I, Khao J, Chami M, Paul-Gilloteaux P, Husain M, Duneau J-P, Stahlberg Henning, Sturgis JN, Scheuring S “Characterization of the motion of membrane proteins using high-speed atomic force microscopy“ Nature Nanotechnology (2012)

• Johannes M, Altmann Karl-Heinz “A ring-closing metathesis-based approach to the synthesis of (+)-tetrabenazine.“ Org Lett. (2012)

• Kudryashev M, Castaño-Díez D, Stahlberg Henning “Limiting factors in single particle cryo electron tomography“ J Struct Biol (2012)

• Bergersen LH, Morland C, Ormel L, Rinholm JE, Larsson M, Wold JF, Roe AT, Stranna A, Santello M, Bouvier D, Ottersen OP, Volterra Andrea, Gundersen V “Immunogold detection of L-glutamate and D-serine in small synaptic-like microvesicles in adult hippocampal astrocytes“ Cerebral Cortex (2012)

• Bréthous L, Garcia-Delgado N, Schwartz J, Bertrand S, Bertrand D, Reymond Jean-Louis “Synthesis and nicotinic receptor activity of chemical space analogues of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide (PNU-282,987) and 1,4-diazabicyclo[3.2.2]nonane-4-carboxylic acid 4-bromophenyl ester (SSR180711)“ J Med Chem (2012)

• Kleyer J, Nicolussi S, Taylor P, Simonelli D, Furger E, Anderle P, Gertsch Jürg “Cannabinoid receptor trafficking in peripheral cells is dynamically regulated by a binary biochemical switch“ Biochem Pharmacol (2012)

• Castaño-Díez D, Kudryashev M, Arheit M, Stahlberg Henning “A flexible, user-friendly development tool for subtomogram averaging of cryo-EM data in High Performance Computing environments“ J Struct Biol (2012)

• Kudryashev M, Stahlberg Henning, Castaño-Díez D “Assessing the benefits of focal pair cryo-electron tomography“ J Struct Biol (2012)

• Castaño-Díez D, Kudryashev M, Arheit M, Stahlberg Henning “Dynamo: A flexible, user-friendly development tool for subtomogram averaging of cryo-EM data in High Performance Computing environments“ J Struct Biol (2012)

• Reymond Jean-Louis, Ruddigkeit L, Blum LC, van Deursen R “The enumeration of chemical space“ WIREs Comput Mol Sci (2012)

• Martorana F, Brambilla L, Valori CF, Bergamaschi C, Roncoroni C, Aronica R, Volterra Andrea, Bezzi P, Rossi D “The BH4 domain of Bcl-X(L) rescues astrocyte degeneration in amyotropic lateral sclerosis by modulating intracellular calcium signals“ Human Molecular Genetis (2012)

• Santello M, Cali C, Bezzi P “Gliotransmission and the tripartite synapse“ Adv Exp Med Biol (2012)

• Simonin J, Vernekar SK, Thompson AJ, Hothersall JD, Connolly CN, Lummis SC, Lochner Martin “High-affinity fluorescent ligands for the 5-HT(3) receptor“ Bioorg Med Chem Lett (2012)

• Stach M, Maillard N, Kadam RU, Kalbermatter D, Meury M, Page MGP, Fotiadis Dimitrios, Darbre T, Reymond Jean-Louis “Membrane disrupting antimicrobial peptide dendrimers with multiple amino termini“ Med Chem Commun. (2012)

• Bürzle M, , Hediger M “Functional and physiological role of vitamin C transporters“ Curr Top Membr (2012)

• Blum LC, van Deursen R, Bertrand S, Mayer M, Bürgi JJ, Bertrand D, Reymond Jean-Louis “ Discovery of a7-Nicotinic Receptor Ligands by Virtual Screening of the Chemical Universe Database GDB-13“ J Chem Inf Model (2011)

• Jeckelmann JM, Harder D, Mari SA, Meury M, Ucurum Z, Müller DJ, Erni B, Fotiadis Dimitrios “Structure and function of the glucose PTS transporter from Escherichia coli“ J Struct Biol. (2011)

• Reymond Jean-Louis, van Deursen R, Bertrand D “What we have learned from crystal structures of proteins to receptor function“ Biochem Pharmacol (2011)

• Marazzi J, Kleyer J, Paredes J-M, Gertsch Jürg “Endocannabinoid content in fetal bovine sera - unexpected effects on mononuclear cells and osteoclastogenesis“ Journal of Immunological Methods (2011)

• Gertsch Jürg “Natural products in chemical biology“ Curr Drug Targets (2011)

• Bergeron MJ, Boggavarapu R, Meury M, Ucurum Z, Caron L, Isenring P, Fotiadis Dimitrios, Hediger M “Frog oocytes to unveil the structure and supramolecular organization of human transport proteins“ PLoS One (2011)

• Blum LC, van Deursen R, Reymond Jean-Louis “Visualisation and subsets of the chemical universe database GDB-13 for virtual screening“ J Comput Aided Mol Des (2011)

• van Deursen R, Blum LC, Reymond Jean-Louis “Visualisation of the chemical space of fragments, lead-like and drug-like molecules in PubChem“ J Comput Aided Mol Des (2011)

• Nikitina L, Wenger F, Baumann M, Körner M, Albrecht Christiane, Surbek D “Expression and localization pattern of ABCA1 in diverse human placental primary cells and tissues“ Placenta (2011)

• Prada I, Marchaland J, Podini P, Magrassi L, D'Alessandro R, Bezzi P, Meldolesi J “REST/NRSF governs the expression of dense-core vesicle gliosecretion in astrocytes“ Journal of Cell Biology (2011)

• Bergeron MJ, Bürzle M, Kovács G, Simonin A, Hediger M “Synthesis, maturation, and trafficking of human Na+-dicarboxylate cotransporter NaDC1 requires the chaperone activity of cyclophilin B“ J Biol Chem (2011)

• Volterra Andrea, Santello M, Bezzi P “TNFα controls glutamatergic gliotransmission in the hippocampal dentate gyrus“ Neuron (2011)

• Mani O, Körner M, Ontsouka EC, Sorensen MT, Sejrsen K, Bruckmaier RM, Albrecht Christiane “Identification of ABCA1 and ABCG1 in milk fat globules and mammary cells – implications in milk cholesterol secretion“ J Dairy Sci (2011)

• Landowski CP, Bolanz KA, Suzuki Y, Hediger M “Chemical inhibitors of the calcium entry channel TRPV6“ Pharm Res (2011)

• Meury M, Harder D, Ucurum Z, Boggavarapu R, Jeckelmann JM, Fotiadis Dimitrios “Structure determination of channel and transport proteins by high-resolution microscopy techniques“ Biol Chem. (2011)

• Volterra Andrea, , Bezzi P “Monitoring exocytosis in astrocytes with total internal reflection fluorescence microscopy“ Cold Spring Harbor (2011)

• Kovács G, Danko T, Bergeron MJ, Balazs B, Suzuki Y, Zsembery A, Hediger M “Heavy metal cations permeate the TRPV6 epithelial cation channel“ Cell Calcium (2011)

• Blum LC, van Deursen R, Reymond Jean-Louis “Exploring the chemical space of known and unkown organic small molecules at www.gdb.unibe.ch“ (2011)

• Simonin A, Fuster Daniel “Nedd4-1 and β-arrestin-1 are key regulators of Na+/H+ exchanger ubiquitylation, endocytosis and function“ J Biol Chem (2010)

• Luethi E, Nguyen KT, Bürzle M, Blum LC, Suzuki Y, Hediger M, Reymond Jean-Louis “Identification of selective norbornane-type aspartate analogue inhibitors of the glutamate transporter 1 (GLT-1) from the chemical universe generated database (GDB)“ J Med Chem (2010)

• Siegrist M, Simonin A, Bonny O, Fuster Daniel, Hofstetter W “Sodium/hydrogen exchanger NHA2 in osteoclasts: Subcellular localization and role in vitro and in vivo“ Bone (2010)

The research network

Publications