Membrane transport and human diseases
Many major human diseases such as diabetes, hypertension, cardiovascular diseases, cancer, osteoporosis, neurodegenerative and psychiatric disorders are related to or are based on the dysfunction of membrane transporters and channels.
Transporters are integral membrane proteins that move important substances such as nutrients, drugs and other substrates across cellular membranes. Because of their importance as cellular gatekeepers, a deep understanding of their structure, functioning and role in diseases if of fundamental significance for advances in basic research and for the development of novel therapeutic drugs.
The research of the NCCR TransCure is characterized by a unique combination of three different scientific disciplines, namely biology/physiology, structural biology and chemistry (referred to as “TransCure Trias”). Scientists from these disciplines team up in multidisciplinary projects that range from fundamental to early stage drug discovery research.