Delalande C, Awale M, Rubin M, Probst D, Ozhathil LC, Gertsch Jürg, Abriel Hugues, Reymond Jean-Louis “Optimizing TRPM4 inhibitors in the MHFP6 chemical space“. Eur J Med Chem. 2019 Mar 15;166:167-177
With the help of sophisticated 3D maps of the chemical space, the researchers designed a structure-activity relationship study of the first potent inhibitor of the TRPM4 cation channel that led to new analogs with improved activity.
Jeckelmann JM, Fotiadis D, “Volta Phase Plate Cryo-EM Structure of the Human Heterodimeric Amino Acid Transporter 4F2hc-LAT2”, Int J Mol Sci. 2019 Feb 21;20(4).
The authors present the first cryo-electron microscopy 3D-map of the human 4F2hc-LAT2 complex. The structure could be determined at ~13 Å resolution.