Petrelli F, Dallérac G, Pucci L, Calì C, Zehnder T, Sultan S, Lecca S, Chicca A, Ivanov A, Asensio CS, Gundersen V, Toni N, Knott GW, Magara F, Gertsch J, Kirchhoff F, Déglon N, Edwards RH, Mothet J-P, Bezzi P,  “Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments“  Molecular Psychiatry  (2018).

In this paper, P. Bezzi and collaborators showed that prefrontal cortex astrocytes play a role in the dopamine modulation of cognitive performances. This has implications for the understanding of psychiatric disorders.

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Häfliger P, Graff J, Rubin M, Stooss A, Dettmer MS, Altmann KH, Gertsch J, Charles RP, “The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model.” J Exp Clin Cancer Res. (2018)

The teams of R.-P. Charles, K.-H. Altmann and J. Gertsch explored the effects of the inhibition of the L-type amino acid transporter 1 (LAT1/SLC7A5) on thyroid carcinoma, and proposed this approach as a novel therapeutic path especially for untreatable thyroid cancers.