Melanie Zechner

My TransCure project in collaboration with the group of Prof. Locher involves the synthesis of fumitremorgin (FTC)-derived inhibitors of the ABCG2 transporter. FTC is a natural product produced by the fungus Aspergillus fumigatus that was first isolated in 1977 by Clardy. The compound is a potent and partly selective inhibitor of the ABCG2 transporter, but it also exhibits profound neurotoxicity. Ko143 is a synthetic analog of FTC, which is not neurotoxic, but retains the ABCG2-inhibitory capacity of the natural product. Our work aims the synthesis of new Ko143 analogs for in vitro functional studies on ABCG2 and to support structural studies.


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Function in NCCR

  • Ph.D. Student

Intern/Extern: Intern