Na+/H+ exchanger NHA2

NHA2 (SLC9B2) is a recently cloned mammalian Na+/H+ exchanger with unknown biological function. Although almost ubiquitously expressed, NHA2 is highly expressed in a subset of specialized cells including osteoclasts, pancreatic β-cells, distal tubular cells of the kidney or neurons. Recent observations in transgenic mice and epidemiological data in humans suggest a possible role of the Na+/H+ exchanger NHA2 in the pathogenesis of diabetes mellitus and arterial hypertension.  The project combines efforts among the TransCure ares of biology and chemistry with the ultimate goal to develop new diagnostic and therapeutic tools for human diseases such as diabetes mellitus and arterial hypertension. Specifically, we seek to elucidate the detailed function and regulation of NHA2 and to develop and characterize small molecule modulators of NHA2 and related intracellular NHEs.