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Projects

Iron transporters DMT1 and FPN

Research team
Dutzler Raimund PI
Albrecht Christiane Co-PI
Hediger Matthias A. Co-PI
Hofstetter Willy Co-PI
Reymond Jean-Louis Co-PI
Awale Mahendra Postdoctoral Fellow
Gyimesi Gergely Postdoctoral Fellow
Kandasamy Palanivel Postdoctoral Fellow
Manatschal Cristina Postdoctoral Fellow
Pujol Gimenez Jonai Postdoctoral Fellow
Cabra Romina Ph.D. Student
Poirier Marion Ph.D. Student
Ramanadane Karthik Ph.D. Student
Zaugg Jonas Ph.D. Student
Amrein Yvonne Technician
Lüthi Michael Technician

Divalent metal ion transporters DMT1 and FPN are vital for iron transport in enterocytes and for transferrin associated endosomal iron transport in many other cell types. Their dysfunction is associated with anemia, iron overload disorders, neurodegenerative diseases (e.g., Parkinson's disease and Alzheimer’s disease), breast and colorectal cancer and autoimmune and inflammatory diseases (e.g., rheumatoid arthritis). The involvement of DMT1 and FPN in these disorders makes their pharmacological modulation a promising therapeutic strategy. The aim of the project is to determine the structure and to characterize the function of divalent metal ion transporters, providing a framework for the development of small molecule modulators and the comprehension of their mechanism of action. Small molecule modulators and binding proteins will be used as tools for physiological studies of iron transport in the placenta and in bone. In addition, they will serve for the investigation of potential therapeutic strategies against the iron overload disorder hemochromatosis, neurodegenerative diseases and osteoporosis.


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